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sites proceeds following an allosteric mechanism with positive cooperativity ( Freye ACIE 2012 , JACS 2013 ). The exchange of larger anions for smaller ones in the outer two pockets leads to a relative motion [...] of both [Pd 2 L 4 ] along the common Pd 4 -axis, thereby enlarging the central cavity ( Freye CEJ 2013 ; Dieterich PCCP 2012 ). In further work, we showed that this can be used to trigger recognition of [...] d guest uptake and release as well as reorganization of small rings into large spheres ( Han ACIE 2013 , ACIE 2016 ; Li JACS 2019 ). In a system combining electron-rich donor and electron-poor acceptor …