A PRACTICAL OVERVIEW OF QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP

A PRACTICAL OVERVIEW OF QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP EXCLI Journal 2010;10:124-127 – ISSN 1611-2156 Received: August 17, 2011, published: August 18, 2011 Editorial: HEPATOTOXICITY P. Godoy [...] toxicology (Hengstler et al., 2009a, b; Gebhardt et al., 2003; Hewitt et al., 2007; Godoy et al., 2010a, b; Meyer et al., 2011). However, following isolation from the liver and attachment to the matrix [...] undergo major alterations, often referred to as dedifferentiation (Godoy et al., 2009; Zellmer et al., 2010). In contradiction to previous concepts, hepatocyte dedifferentiation is not a passive process during …